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BAP1
BAP1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC |
|---|---|
| Primary Accession | Q92560 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone Names | poly |
| Calculated MW | 80362 Da |
| Gene ID | 8314 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase BAP1, 3.4.19.12, BRCA1-associated protein 1, Cerebral protein 6 {ECO:0000303|Ref.2}, BAP1 {ECO:0000303|PubMed:9528852, ECO:0000312|HGNC:HGNC:950} |
| Dilution | IHC~~1:100~500 |
| Storage | Maintain refrigerated at 2-8°C |
| Precautions | BAP1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BAP1 {ECO:0000303|PubMed:9528852, ECO:0000312|HGNC:HGNC:950} |
|---|---|
| Function | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922). Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:25451922). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N- terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor (PubMed:9528852). |
| Cellular Location | Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950) |
| Tissue Location | Highly expressed in testis, placenta and ovary. Expressed in breast. |
Research Areas
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Application Protocols
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$ 106.00
Cat# AD80566-010
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